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Doi No: 10.5578/mb.9135

Kahramanmaraş'ta Saptanan İki Viseral Leyşmanyazis Olgusu

Two Cases of Visceral Leishmaniasis from Kahramanmaraş, Turkey

İlkay KARAOĞLAN1, Fahriye EKŞİ2, Handan HAYDAROĞLU ŞAHİN3, Mustafa PEHLİVAN3, Sema TEKİN ŞAHİN1,
Vuslat KEÇİK BOŞNAK1, Muhammed BİLİCİ4, Mustafa NAMIDURU1, Tekin KARSLIGİL2


1 Gaziantep Üniversitesi Tıp Fakültesi, Enfeksiyon Hastalıkları Anabilim Dalı, Gaziantep.

1 Gaziantep University Faculty of Medicine, Department of Infectious Diseases, Gaziantep, Turkey.

2 Gaziantep Üniversitesi Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı, Gaziantep.

2 Gaziantep University Faculty of Medicine, Department of Medical Microbiology, Gaziantep, Turkey.

3 Gaziantep Üniversitesi Tıp Fakültesi, Hematoloji Bilim Dalı, Gaziantep.

3 Gaziantep University Faculty of Medicine, Department of Hematology, Gaziantep, Turkey.

4 Gaziantep Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Gaziantep.

4 Gaziantep University Faculty of Medicine, Department of Internal Medicine, Gaziantep, Turkey.

ABSTRACT

Turkey is an endemic area for cutaneous leishmaniasis (CL) according to the data of World Health Organization. CL is more widely distributed in Sanliurfa region (located at south-eastern part of Anatolia) of Turkey, while visceral leishmaniasis (VL) is reported sporadically from all parts of Turkey, especially in pediatric cases. However VL has not been reported from our region yet. Here we report two cases of VL from Kahramanmaraş region (located at eastern part of South Anatolia), one of which was a 57-year-old immuncompromised patient and the other was a 18-year-old immunocompetent patient. The common symptoms of the patients were high fever, hepatosplenomegaly and pancytopenia. The diagnosis of both patients was made by demonstration of the amastigotes of parasite in Giemsa-stained smears prepared from bone marrow aspiration samples, and isolation of promastigotes from cultures in NNN medium. The isolates were identified as Leishmania donovani with PCR and sequencing methods. Both of the patients were treated successfully with liposomal amphotericin B, resulting in complete cure. In conclusion, cases with fever of unknown origin, hepatosplenomegaly, pancytopenia and hypergammaglobulinemia should be considered in terms of VL especially in Kahramanmaraş region.

Keywords: Visceral leishmaniasis; culture; polymerase chain reaction; Turkey.

Geliş Tarihi (Received): 01.09.2014 - Kabul Ediliş Tarihi (Accepted): 25.02.2015

İletişim (Correspondence):

Doç. Dr. İlkay Karaoğlan,

Gaziantep Üniversitesi Şahinbey Araştırma ve

Uygulama Hastanesi, Enfeksiyon Hastalıkları Anabilim Dalı,

27310 Şehitkamil, Gaziantep, Türkiye.

Tel (Phone): +90 0342 360 6060/76700,

E-posta (E-mail): ikaraoglan10@hotmail.com

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