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Doi No: 10.5578/mb.9332

Hemofagositik Sendrom Sebebi Olarak Bruselloz

Brucellosis as a Cause of Hemophagocytic Syndrome

Saliha AYDIN1, Özgür GÜNAL1, Mehmet Hakan TAŞKIN2, Aynur ATİLLA1, Süleyman Sırrı KILIÇ1

1 Samsun Education and Training Hospital, Department of Infectious Diseases and Clinical Microbiology, Samsun, Turkey.

1 Samsun Eğitim Araştırma Hastanesi, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, Samsun.

2 Samsun Education and Training Hospital, Department of Medical Microbiology, Samsun, Turkey.

2 Samsun Eğitim Araştırma Hastanesi, Tıbbi Mikrobiyoloji Anabilim Dalı, Samsun.


Hemophagocytic lymphohistiocytosis (HLH) is a rare syndrome of excessive inflammation and tissue destruction due to abnormal immune activation and inflammation. HLH can occur primarily due to genetic etiology, or secondarily associated with malignancies, autoimmmune diseases or infections. There are a number of reports that revealed the relationship of hemophagocytosis with brucellosis. In this report, we described a brucellosis-related HLH case. A 73-year-old male who work as farmer was admitted to our hospital with the complaints of fever continuing for 10 days, loss of appetite and back pain. Physical examination revealed right upper quadrant tenderness and hepatomegaly. Since the patient exhibited five of the diagnostic criteria for HLH (fever, hepatosplenomegaly, bicytopenia, hypertriglyceridemia and high ferritin level), he was diagnosed as secondary HLH. PCR, microscopic agglutination and indirect fluorescent antibody tests gave negative results for the diagnosis of Crimean-Congo hemorrhagic fever, leptospirosis and Q fever, respectively. On the other hand, Rose Bengal test for brucellosis was positive, while standard tube agglutination test (STA) was negative. The patient's serum yielded a very high positive (1/1280) result when Coombs' test was performed in terms of the possibility of blocking antibodies or prozone phenomenon. Additionally, B.melitensis was isolated from his blood culture on the sixth day. The patient was treated with doxycycline and rifampicin, and on the 10th day of antibiotic therapy the patient was discharged and recommended to complete his treatment up to 6 weeks. In conclusion, in patients with secondary HLH symptoms especially in the endemic areas, brucellosis should be considered as a predisposing infection.

Keywords: Hemophagocytic lymphohistiocytosis; Brucella; brucellosis.

Geliş Tarihi (Received): 04.09.2014 - Kabul Ediliş Tarihi (Accepted): 18.03.2015

İletişim (Correspondence):

Dr. Saliha Aydın,

Samsun Eğitim Araştırma Hastanesi,

Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı,

55100 Samsun, Türkiye.

Tel (Phone): +90 362 311 1500,

E-posta (E-mail): saliha_meva@hotmail.com

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